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Title:

Acute valproate poisoning: pharmacokinetics, alteration in fatty acid metabolism, and changes during therapy.

Document type:
Case Reports; Journal Article; Article
Author(s):
Eyer, F; Felgenhauer, N; Gempel, K; Steimer, W; Gerbitz, KD; Zilker, T
Abstract:
The clinical features, complications, and pharmacokinetics of intentional acute valproic acid (VPA) overdoses are described. Alteration in fatty acid metabolism is evaluated and therapy-induced changes are discussed. Central nervous system features were the predominant clinical manifestations (6/6), followed by respiratory failure (5/6) and multiorgan failure (2/6). Mechanical ventilation was required in 5 of 6 patients because of respiratory depression or deep coma. Hemodialysis was applied in...     »
Journal title abbreviation:
J Clin Psychopharmacol
Year:
2005
Journal volume:
25
Journal issue:
4
Pages contribution:
376-80
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16012283
Print-ISSN:
0271-0749
TUM Institution:
2. Medizinische Klinik Toxikologische Abteilung (alt) (Prof. Zilker); Institut für Klinische Chemie und Pathobiochemie
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