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Titel:

Rac regulates thrombin-induced tissue factor expression in pulmonary artery smooth muscle cells involving the nuclear factor-kappaB pathway.

Dokumenttyp:
Journal Article
Autor(en):
Djordjevic, T; Hess, J; Herkert, O; Gorlach, A; BelAiba, RS
Abstract:
Pulmonary hypertension is associated with enhanced thrombogenicity of the vessel wall contributing to vascular remodeling. However, the signaling mechanisms promoting this prothrombotic state are not resolved. Here we investigated the role of the GTPase Rac in the regulation of tissue factor (TF) expression and activity in response to thrombin in pulmonary artery smooth muscle cells (PASMC). TF mRNA and protein expression and surface procoagulant activity were increased by thrombin in PASMC. The...     »
Zeitschriftentitel:
Antioxid Redox Signal
Jahr:
2004
Band / Volume:
6
Heft / Issue:
4
Seitenangaben Beitrag:
713-20
Sprache:
eng
Volltext / DOI:
doi:10.1089/1523086041361703
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15242552
Print-ISSN:
1523-0864
TUM Einrichtung:
Klinik für Kinderkardiologie und angeborene Herzfehler (Prof. Hess)
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