Late rectal symptoms and quality of life after conformal radiation therapy for prostate cancer.

Geinitz, H; Zimmermann, FB; Thamm, R; Erber, C; Müller, T; Keller, M; Busch, R; Molls, M

doi:10.1016/j.radonc.2006.05.004

journal article

Titel:: Late rectal symptoms and quality of life after conformal radiation therapy for prostate cancer.
Dokumenttyp:: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):: Geinitz, H; Zimmermann, FB; Thamm, R; Erber, C; Müller, T; Keller, M; Busch, R; Molls, M
Abstract:: BACKGROUND AND PURPOSE: This study was carried out in order to analyze the prevalence of late rectal and anal symptoms after conformal radiation therapy for prostate cancer and to assess their association with quality of life. PATIENTS AND METHODS: Two-hundred and forty nine patients were interviewed at 24-111 months after definitive conformal radiation therapy of localized prostate cancer with a median dose of 70 Gy. Rectal symptoms and fecal incontinence were evaluated with standardized questionnaires. Quality of life was assessed with the EORTC Quality of Life Questionnaire-C30 and the prostate cancer module PR25. RESULTS: Rectal symptoms were mostly intermittent. Daily symptoms occurred in < or =5% of the patients. Incontinence was mostly mild with only 3% of the patients reporting daily incontinence episodes. Quality of life was comparable to that of the male German general population except that cognitive functioning and diarrhea were worse in the study population and pain was worse in the reference population. Global quality of life was associated with fecal incontinence, fecal urge, tenesmus, therapy for rectal symptoms and hormonal therapy for biochemical/clinical recurrence. CONCLUSIONS: Rectal symptoms and fecal incontinence after conformal radiation therapy for prostate cancer are mostly intermittent. Fecal incontinence, fecal urge and tenesmus are associated with lower global quality of life levels.
Zeitschriftentitel:: Radiother Oncol
Jahr:: 2006
Band / Volume:: 79
Heft / Issue:: 3
Seitenangaben Beitrag:: 341-7
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.radonc.2006.05.004
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/16733072
Print-ISSN:: 0167-8140
TUM Einrichtung:: Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für RadioOnkologie und Strahlentherapie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für KI und Informatik in der Medizin (Prof. Rückert)2006

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für RadioOnkologie und Strahlentherapie (Prof. Combs)2006