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Title:

The Ras inhibitors caveolin-1 and docking protein 1 activate peroxisome proliferator-activated receptor ? through spatial relocalization at helix 7 of its ligand-binding domain.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Burgermeister, E; Friedrich, T; Hitkova, I; Regel, I; Einwächter, H; Zimmermann, W; Röcken, C; Perren, A; Wright, MB; Schmid, RM; Seger, R; Ebert, MP
Abstract:
Peroxisome proliferator-activated receptor ? (PPAR?) is a transcription factor that promotes differentiation and cell survival in the stomach. PPAR? upregulates and interacts with caveolin-1 (Cav1), a scaffold protein of Ras/mitogen-activated protein kinases (MAPKs). The cytoplasmic-to-nuclear localization of PPAR? is altered in gastric cancer (GC) patients, suggesting a so-far-unknown role for Cav1 in spatial regulation of PPAR? signaling. We show here that loss of Cav1 accelerated proliferatio...     »
Journal title abbreviation:
Mol Cell Biol
Year:
2011
Journal volume:
31
Journal issue:
16
Pages contribution:
3497-510
Language:
eng
Fulltext / DOI:
doi:10.1128/MCB.01421-10
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21690289
Print-ISSN:
0270-7306
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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