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Title:

Myeloid, but not pancreatic, RelA/p65 is required for fibrosis in a mouse model of chronic pancreatitis.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Treiber, M; Neuhöfer, P; Anetsberger, E; Einwächter, H; Lesina, M; Rickmann, M; Liang, S; Kehl, T; Nakhai, H; Schmid, RM; Algul, H
Abstract:
Little is known about how transcription factors might regulate pathogenesis of chronic pancreatitis (CP). We analyzed the in vivo role of RelA/p65, a component of the transcription factor nuclear factor (NF)-?B, in different cell types during development of CP in mice.RelA/p65 was functionally inactivated in the pancreas (rela?panc), in myeloid cells (rela?mye), or both (rela?panc,?mye) compartments using the Cre-loxP strategy. Experimental CP was induced with repetitive injections of cerulein o...     »
Journal title abbreviation:
Gastroenterology
Year:
2011
Journal volume:
141
Journal issue:
4
Pages contribution:
1473-85, 1485.e1-7
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2011.06.087
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21763242
Print-ISSN:
0016-5085
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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