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Title:

Mechanisms of everolimus-induced glomerulosclerosis after glomerular injury in the rat.

Document type:
Journal Article
Author(s):
Daniel, C; Renders, L; Amann, K; Schulze-Lohoff, E; Hauser, IA; Hugo, C
Abstract:
Despite the lack of nephrotoxicity, adverse effects of the new antiproliferative immunosuppressant everolimus have been reported. By varying time point and dose of everolimus treatment as well as the degree of glomerular injury, the specific conditions and potential mechanisms leading to adverse actions in the anti-Thy1 model have been determined. Only the combination of early and high-dose everolimus treatment (1-3 mg/kg bw) with a severe glomerular lesion ('full-dose' anti-Thy1 model) caused a...     »
Journal title abbreviation:
Am J Transplant
Year:
2005
Journal volume:
5
Journal issue:
12
Pages contribution:
2849-61
Fulltext / DOI:
doi:10.1111/j.1600-6143.2005.01120.x
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16302997
Print-ISSN:
1600-6135
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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