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Title:

Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats.

Document type:
Journal Article; Article
Author(s):
Neuhofer, W; Holzapfel, K; Fraek, ML; Ouyang, N; Lutz, J; Beck, FX
Abstract:
BACKGROUND: Papillary cells adapt to their hyperosmotic environment by accumulating organic osmolytes and by enhanced synthesis of heat shock protein 70 (HSP70), which protect against high-solute concentrations. Because cyclooxygenase-2 (COX-2) is expressed abundantly in the renal papilla and is induced by dehydration, and because HSP70 expression is stimulated by specific prostaglandins, COX-2 inhibition may interfere with cellular osmoadaptation. METHODS: In vivo, rats received rofecoxib befor...     »
Journal title abbreviation:
Kidney Int
Year:
2004
Journal volume:
65
Journal issue:
2
Pages contribution:
431-41
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14717913
Print-ISSN:
0085-2538
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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