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Title:

Suppressed T-cell activation by IFN-gamma-induced expression of PD-L1 on renal tubular epithelial cells.

Document type:
Journal Article; Article
Author(s):
Schoop, R; Wahl, P; Le Hir, M; Heemann, U; Wang, M; Wüthrich, RP
Abstract:
BACKGROUND: The interaction of the T-cell molecule PD-1 (programmed death-1) with its ligands PD-L1 and PD-L2 represents a known mechanism of T-cell inhibition. PD-1 is homologous to CD28 while the PD-1 ligands share homology with the B7 family of co-stimulatory molecules. METHODS: We have studied surface expression and transcript levels of PD-L1 and PD-L2 on murine renal tubular epithelial cells (TEC) by flow cytometric analysis and reverse transcription-polymerase chain reaction. Western blot...     »
Journal title abbreviation:
Nephrol Dial Transplant
Year:
2004
Journal volume:
19
Journal issue:
11
Pages contribution:
2713-20
Language:
eng
Fulltext / DOI:
doi:10.1093/ndt/gfh423
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15353579
Print-ISSN:
0931-0509
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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