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Titel:

Chronic COX-2 inhibition reduces medullary HSP70 expression and induces papillary apoptosis in dehydrated rats.

Dokumenttyp:
Journal Article; Article
Autor(en):
Neuhofer, W; Holzapfel, K; Fraek, ML; Ouyang, N; Lutz, J; Beck, FX
Abstract:
BACKGROUND: Papillary cells adapt to their hyperosmotic environment by accumulating organic osmolytes and by enhanced synthesis of heat shock protein 70 (HSP70), which protect against high-solute concentrations. Because cyclooxygenase-2 (COX-2) is expressed abundantly in the renal papilla and is induced by dehydration, and because HSP70 expression is stimulated by specific prostaglandins, COX-2 inhibition may interfere with cellular osmoadaptation. METHODS: In vivo, rats received rofecoxib befor...     »
Zeitschriftentitel:
Kidney Int
Jahr:
2004
Band / Volume:
65
Heft / Issue:
2
Seitenangaben Beitrag:
431-41
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14717913
Print-ISSN:
0085-2538
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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