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Title:

Relevance of tumor microenvironment for progression, therapy and drug development.

Document type:
journal article
Author(s):
Henning, T; Kraus, M; Brischwein, M; Otto, AM; Wolf, B
Abstract:
Tumor interstitium exhibits a microenvironment that differs from corresponding normal tissues. Tumor phenotype shows, for example, an elevated intracellular pH (pHi), a lowered extracellular pH (pHe), a low oxygen concentration and low glucose levels. These differences are caused by cell biological (so called intrinsic) factors, e.g. a higher acidification rate, as well as by more systemic (extrinsic) factors, e.g. poor tumor vascularization. They represent important factors for invasiveness, im...     »
Journal title abbreviation:
Anticancer Drugs
Year:
2004
Journal volume:
15
Journal issue:
1
Pages contribution:
7-14
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15090737
Print-ISSN:
0959-4973
TUM Institution:
Institut für Radiologie
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