[Multislice-CT for structure analysis of trabecular bone - a comparison with micro-CT and biomechanical strength]

Bauer, JS; Issever, AS; Fischbeck, M; Burghardt, A; Eckstein, F; Rummeny, EJ; Majumdar, S; Link, TM

2004

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Title:: [Multislice-CT for structure analysis of trabecular bone - a comparison with micro-CT and biomechanical strength]
Document type:: journal article
Author(s):: Bauer, JS; Issever, AS; Fischbeck, M; Burghardt, A; Eckstein, F; Rummeny, EJ; Majumdar, S; Link, TM
Abstract:: OBJECTIVES: MS-CT (Multislice-Spiral-CT) has a higher spatial resolution compared to the SS-CT (Singleslice-CT). The purpose of this study was to investigate, if the higher spatial resolution of the MS-CT has advantages for structural analyses in the assessment of osteoporosis. MATERIAL AND METHODS: 20 cylindrical trabecular bone specimens (diameter 12 mm, length 15 - 20 mm) were harvested from formalin-fixed human thoracic spines. All specimens were examined by Micro-CT and quantitative, histomorphologic parameters were determined. Analogous structural parameters were calculated from the high-resolution images acquired by both MS- and SS-CT. Additionally, the BMD (bone mineral density) was measured by QCT (quantitative CT). The maximum compressive strength (MCS) was determined in a biomechanical test. The structural parameters were correlated with the histomorphologic parameters and with the MCS. RESULTS: The parameters bone fraction and trabecular separation correlated significantly in both MS- and SS-CT with the analogous parameters from Micro-CT (r (2) = 0.84, p< 0.01) and the MCS (r (2) = 0.81, p< 0.01). The highest correlation with the MCS was calculated using the trabecular number measured by MS-CT in the superior region near the endplate of the vertebra with the high-resolution kernel U90 u (r (2) = 0.85, p< 0.01). This correlation was significantly higher than the correlation between MCS and BMD (r (2) = 0.49, p< 0.01). CONCLUSION: Micro-CT- and MS-CT-determined structural parameters of the trabecular bone showed significant, high correlations. Thus, a characterisation of the trabecular structure seems to be possible. The biomechanical stability of the bone can also be predicted well. The structural parameters acquired by MS-CT show higher correlations with the MCS than the BMD or structural parameters determined by SS-CT do. In this study MS-CT was best suited to predict biomechanical strength of trabecular bone.
Journal title abbreviation:: Rofo
Year:: 2004
Journal volume:: 176
Journal issue:: 5
Pages contribution:: 709-18
Language:: de
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/15122470
Print-ISSN:: 1438-9029
TUM Institution:: Institut für Radiologie
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Institut für Diagnostische und Interventionelle Radiologie (Prof. Makowski)Institut für Radiologie und Nuklearmedizin 2004

mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Ehemalige Einrichtungen Lehrstuhl für Röntgendiagnostik (Prof. Rummeny)