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Titel:

Relevance of tumor microenvironment for progression, therapy and drug development.

Dokumenttyp:
journal article
Autor(en):
Henning, T; Kraus, M; Brischwein, M; Otto, AM; Wolf, B
Abstract:
Tumor interstitium exhibits a microenvironment that differs from corresponding normal tissues. Tumor phenotype shows, for example, an elevated intracellular pH (pHi), a lowered extracellular pH (pHe), a low oxygen concentration and low glucose levels. These differences are caused by cell biological (so called intrinsic) factors, e.g. a higher acidification rate, as well as by more systemic (extrinsic) factors, e.g. poor tumor vascularization. They represent important factors for invasiveness, im...     »
Zeitschriftentitel:
Anticancer Drugs
Jahr:
2004
Band / Volume:
15
Heft / Issue:
1
Seitenangaben Beitrag:
7-14
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15090737
Print-ISSN:
0959-4973
TUM Einrichtung:
Institut für Radiologie
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