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- Title:
Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer.
- Document type:
- journal article
- Author(s):
- Simon, GH; Fu, Y; Berejnoi, K; Fournier, LS; Lucidi, V; Yeh, B; Shames, DM; Brasch, RC
- Abstract:
- OBJECTIVE: The objective of this study was to evaluate computed tomography (CT) enhancement characteristics for a new iodinated macromolecular contrast medium (MMCM), PEG12000-Gen4-triiodo, for angiographic effect and for assessment of abnormal vascular permeability in cancer. MATERIALS AND METHODS: Time persistence of angiographic effect was evaluated on rat CT images acquired over 30 minutes using the iodinated polyethyleneglycol- (PEG) based macromolecule. Dynamic CT imaging after PEG12000-Gen4-triiodo-enhancement in tumor-bearing rats was used to quantitatively estimate plasma volume and microvascular transendothelial permeability for both tumor and normal soft tissue. Using identical doses of iodine, 300 mg iodine/kg, blood curves for this MMCM and iohexol were compared. RESULTS: Serial whole-body CT angiograms using PEG12000-Gen4-triiodo showed diagnostic vascular detail through 20 minutes, and the blood enhancement curve was higher and more persistent than with small-molecular iohexol. Permeability estimates were significantly (P<0.02; paired t test) higher in tumors (48.2+/-18.1 microL/min-1 100 mL) than in muscle (2.5+/-5.7 microL/min-1 100 mL). CONCLUSIONS: Use of PEG-based MMCM for experimental CT allowed for a persistent angiographic enhancement and for quantitative estimation of tumor microvascular characteristics.
- Journal title abbreviation:
- Invest Radiol
- Year:
- 2005
- Journal volume:
- 40
- Journal issue:
- 9
- Pages contribution:
- 614-20
- Language:
- eng
- Pubmed ID:
- http://view.ncbi.nlm.nih.gov/pubmed/16118555
- Print-ISSN:
- 0020-9996
- TUM Institution:
- Institut für Radiologie
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