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Titel:

Initial computed tomography imaging experience using a new macromolecular iodinated contrast medium in experimental breast cancer.

Dokumenttyp:
journal article
Autor(en):
Simon, GH; Fu, Y; Berejnoi, K; Fournier, LS; Lucidi, V; Yeh, B; Shames, DM; Brasch, RC
Abstract:
OBJECTIVE: The objective of this study was to evaluate computed tomography (CT) enhancement characteristics for a new iodinated macromolecular contrast medium (MMCM), PEG12000-Gen4-triiodo, for angiographic effect and for assessment of abnormal vascular permeability in cancer. MATERIALS AND METHODS: Time persistence of angiographic effect was evaluated on rat CT images acquired over 30 minutes using the iodinated polyethyleneglycol- (PEG) based macromolecule. Dynamic CT imaging after PEG12000-Gen4-triiodo-enhancement in tumor-bearing rats was used to quantitatively estimate plasma volume and microvascular transendothelial permeability for both tumor and normal soft tissue. Using identical doses of iodine, 300 mg iodine/kg, blood curves for this MMCM and iohexol were compared. RESULTS: Serial whole-body CT angiograms using PEG12000-Gen4-triiodo showed diagnostic vascular detail through 20 minutes, and the blood enhancement curve was higher and more persistent than with small-molecular iohexol. Permeability estimates were significantly (P<0.02; paired t test) higher in tumors (48.2+/-18.1 microL/min-1 100 mL) than in muscle (2.5+/-5.7 microL/min-1 100 mL). CONCLUSIONS: Use of PEG-based MMCM for experimental CT allowed for a persistent angiographic enhancement and for quantitative estimation of tumor microvascular characteristics.
Zeitschriftentitel:
Invest Radiol
Jahr:
2005
Band / Volume:
40
Heft / Issue:
9
Seitenangaben Beitrag:
614-20
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16118555
Print-ISSN:
0020-9996
TUM Einrichtung:
Institut für Radiologie
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