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Titel:

Helicobacter pylori HopH (OipA) and bacterial pathogenicity: genetic and functional genomic analysis of hopH gene polymorphisms.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Dossumbekova, A; Prinz, C; Mages, J; Lang, R; Kusters, JG; Van Vliet, AH; Reindl, W; Backert, S; Saur, D; Schmid, RM; Rad, R
Abstract:
BACKGROUND: Expression of the Helicobacter pylori outer membrane protein HopH is regulated by phase variation within a CT dinucleotide repeat motif of the hopH gene. METHODS: To investigate the importance of HopH for bacterial pathogenicity, we performed a detailed functional genomic and population-based genetic characterization of this contingency locus. RESULTS: Sequencing of hopH in H. pylori strains from 58 patients revealed that the hopH "on" genotype is linked to bacterial virulence determ...     »
Zeitschriftentitel:
J Infect Dis
Jahr:
2006
Band / Volume:
194
Heft / Issue:
10
Seitenangaben Beitrag:
1346-55
Sprache:
eng
Volltext / DOI:
doi:10.1086/508426
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/17054063
Print-ISSN:
0022-1899
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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