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Title:

The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Bauer, A; Villunger, A; Labi, V; Fischer, SF; Strasser, A; Wagner, H; Schmid, RM; Häcker, G
Abstract:
Apoptosis of activated T cells is critical for the termination of immune responses. Here we show that adjuvant-stimulated dendritic cells secrete cytokines that prime activated T cells for survival and analyze the roles of the NF-kappaB regulator Bcl-3 and the proapoptotic Bcl-2 family members Bim and Puma. Bcl-3 overexpression increased survival, and activated bcl-3-/- T cells died abnormally rapidly. Cytokines from adjuvant-stimulated dendritic cells induced Bcl-3, but survival through cytokin...     »
Journal title abbreviation:
Proc Natl Acad Sci U S A
Year:
2006
Journal volume:
103
Journal issue:
29
Pages contribution:
10979-84
Language:
eng
Fulltext / DOI:
doi:10.1073/pnas.0603625103
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16832056
Print-ISSN:
0027-8424
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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