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Title:

GADD45alpha is highly expressed in pancreatic ductal adenocarcinoma cells and required for tumor cell viability.

Document type:
Journal Article
Author(s):
Schneider, G; Weber, A; Zechner, U; Oswald, F; Friess, HM; Schmid, RM; Liptay, S
Abstract:
Pancreatic ductal adenocarcinoma is one of the most common causes of cancer death in the western civilization. Recently, NF-kappaB has been shown to be activated in pancreatic ductal adenocarcinoma through constitutive activation of IkappaB kinase (IKK). Inhibition of NF-kappaB by a super-inhibitor of NF-kappaB--delta-N-IkappaBalpha--resulted in impaired proliferation and induction of apoptosis, suggesting an important role of NF-kappaB in pancreatic tumorigenesis. Downstream target genes of Ika...     »
Journal title abbreviation:
Int J Cancer
Year:
2006
Journal volume:
118
Journal issue:
10
Pages contribution:
2405-11
Language:
eng
Fulltext / DOI:
doi:10.1002/ijc.21637
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16353139
Print-ISSN:
0020-7136
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Klinik und Poliklinik für Kinderheilkunde und Jugendmedizin
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