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Title:

Constitutive activation of NF-kappaB in human hepatocellular carcinoma: evidence of a cytoprotective role.

Document type:
Journal Article; Article
Author(s):
Qiao, L; Zhang, H; Yu, J; Francisco, R; Dent, P; Ebert, MP; Röcken, C; Farrell, G
Abstract:
Activation of nuclear factor-kappaB (NF-kappaB) can promote or inhibit apoptosis. Oxidative stress is an important mechanism by which certain anticancer drugs kill cancer cells, and is also one of the mechanisms that activate NF-kappaB. We therefore examined hepatic expression of the NF-kappaB monomer p65 in human hepatocellular carcinoma (HCC) tissue samples from eight patients and compared it with their respective samples of surrounding liver tissues. We also studied the effect of NF-kappaB in...     »
Journal title abbreviation:
Hum Gene Ther
Year:
2006
Journal volume:
17
Journal issue:
3
Pages contribution:
280-90
Language:
eng
Fulltext / DOI:
doi:10.1089/hum.2006.17.280
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16544977
Print-ISSN:
1043-0342
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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