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Title:

Association of DNA methylation of phosphoserine aminotransferase with response to endocrine therapy in patients with recurrent breast cancer.

Document type:
Journal Article; Article
Author(s):
Martens, JW; Nimmrich, I; Koenig, T; Look, MP; Harbeck, N; Model, F; Kluth, A; Bolt-de Vries, J; Sieuwerts, AM; Portengen, H; Meijer-Van Gelder, ME; Piepenbrock, C; Olek, A; Höfler, H; Kiechle, M; Klijn, JG; Schmitt, M; Maier, S; Foekens, JA
Abstract:
To understand the biological basis of resistance to endocrine therapy is of utmost importance in patients with steroid hormone receptor-positive breast cancer. Not only will this allow us prediction of therapy success, it may also lead to novel therapies for patients resistant to current endocrine therapy. DNA methylation in the promoter regions of genes is a prominent epigenetic gene silencing mechanism that contributes to breast cancer biology. In the current study, we investigated whether pro...     »
Journal title abbreviation:
Cancer Res
Year:
2005
Journal volume:
65
Journal issue:
10
Pages contribution:
4101-17
Language:
eng
Fulltext / DOI:
doi:10.1158/0008-5472.CAN-05-0064
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15899800
Print-ISSN:
0008-5472
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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