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Titel:

Urokinase-type plasminogen activator and its inhibitor type 1 predict disease outcome and therapy response in primary breast cancer.

Dokumenttyp:
Journal Article; Review
Autor(en):
Harbeck, N; Kates, RE; Schmitt, M; Gauger, K; Kiechle, M; Janicke, F; Thomassen, C; Look, MP; Foekens, JA
Abstract:
Combined determination of urokinase-type plasminogen activator (uPA) and its inhibitor, activator inhibitor type 1 (PAI-1), supports risk-adapted individualized therapy concepts, particularly in node-negative breast cancer. The prognostic impact of both factors in primary breast cancer was substantiated by a pooled analysis of > 8000 patients with breast cancer and a multicenter prospective randomized therapy trial in node-negative breast cancer; findings achieved the highest level of evidence...     »
Zeitschriftentitel:
Clin Breast Cancer
Jahr:
2004
Band / Volume:
5
Heft / Issue:
5
Seitenangaben Beitrag:
348-52
Sprache:
eng
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15585071
Print-ISSN:
1526-8209
TUM Einrichtung:
Frauenklinik und Poliklinik
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