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Title:

Differential splicing generates new transmembrane receptor and extracellular matrix-related targets for antibody-based therapy of cancer.

Document type:
Journal Article; Review
Author(s):
Weidle, UH; Maisel, D; Klostermann, S; WEISS, EH; Schmitt, M
Abstract:
Alternative splicing has been shown to be deregulated in cancer and a link to growth stimulation has been established. Here we describe transmembrane and extracellular matrix-related targets generated by alternative splicing with a restricted pattern of expression in normal tissues and a deregulated pattern of expression in cancer as possible targets for therapeutic intervention with antibody-related agents. We focus on isoforms of transmembrane and extracellular matrix proteins, such as CD44, C...     »
Journal title abbreviation:
Cancer Genomics Proteomics
Year:
2011
Journal volume:
8
Journal issue:
5
Pages contribution:
211-26
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21980036
Print-ISSN:
1109-6535
TUM Institution:
Frauenklinik und Poliklinik
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