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Title:

Multicenter validation of a gene expression-based prognostic signature in lymph node-negative primary breast cancer.

Document type:
Journal Article; Article
Author(s):
Foekens, JA; Atkins, D; Zhang, Y; Sweep, FC; Harbeck, N; Paradiso, A; Cufer, T; Sieuwerts, AM; Talantov, D; Span, PN; Tjan-Heijnen, VC; Zito, AF; Specht, K; Hoefler, H; Golouh, R; Schittulli, F; Schmitt, M; Beex, LV; Klijn, JG; Wang, Y
Abstract:
PURPOSE: We previously identified in a single-center study a 76-gene prognostic signature for lymph node-negative (LNN) breast cancer patients. The aim of this study was to validate this gene signature in an independent more diverse population of LNN patients from multiple institutions. PATIENTS AND METHODS: Using custom-designed DNA chips we analyzed the expression of the 76 genes in RNA of frozen tumor samples from 180 LNN patients who did not receive adjuvant systemic treatment. RESULTS: In t...     »
Journal title abbreviation:
J Clin Oncol
Year:
2006
Journal volume:
24
Journal issue:
11
Pages contribution:
1665-71
Language:
eng
Fulltext / DOI:
doi:10.1200/JCO.2005.03.9115
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16505412
Print-ISSN:
0732-183X
TUM Institution:
Frauenklinik und Poliklinik; Institut für Allgemeine Pathologie und Pathologische Anatomie
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