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Title:

Local cyclin-dependent kinase inhibition by flavopiridol inhibits coronary artery smooth muscle cell proliferation and migration: Implications for the applicability on drug-eluting stents to prevent neointima formation following vascular injury.

Document type:
Journal Article; Article
Author(s):
Jaschke, B; Milz, S; Vogeser, M; Michaelis, C; Vorpahl, M; Schömig, A; Kastrati, A; Wessely, R
Abstract:
In-stent restenosis is a hyperproliferative disease which can be successfully treated by drug-eluting stents releasing compounds that exhibit cell-cycle inhibitory properties to inhibit coronary smooth muscle cell (CASMC) proliferation and migration, resembling the key pathomechanisms of in-stent restenosis. Cyclin-dependent kinases (CDK) are key regulators of the eukaryotic cell cycle. CDK activity may be blocked by novel compounds such as flavopiridol. Therefore, CDK inhibitors are attractive...     »
Journal title abbreviation:
FASEB J
Year:
2004
Journal volume:
18
Journal issue:
11
Pages contribution:
1285-7
Language:
eng
Fulltext / DOI:
doi:10.1096/fj.04-1646fje
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15180955
Print-ISSN:
0892-6638
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Experimentelle Onkologie und Therapieforschung
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