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Titel:

Glypican-3 is involved in cellular protection against mitoxantrone in gastric carcinoma cells.

Dokumenttyp:
Journal Article
Autor(en):
Wichert, A; Stege, A; Midorikawa, Y; Holm, PS; Lage, H
Abstract:
Elevated expression of the heparan sulphate proteoglycan glypican-3 (GPC3) was found on mRNA and protein levels in the atypical multidrug-resistant gastric carcinoma cell line EPG85-257RNOV, which was established by in vitro selection against mitoxantrone. In order to elucidate a putative role of GPC3 in the drug-resistant phenotype, the mitoxantrone-resistant cell line EPG85-257RNOV was transfected with an expression vector construct carrying an anti-GPC3 hammerhead ribozyme. It could be demons...     »
Zeitschriftentitel:
Oncogene
Jahr:
2004
Band / Volume:
23
Heft / Issue:
4
Seitenangaben Beitrag:
945-55
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1207237
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14661052
Print-ISSN:
0950-9232
TUM Einrichtung:
Institut für Experimentelle Onkologie und Therapieforschung
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