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Title:

The urokinase receptor (uPAR, CD87) as a target for tumor therapy: uPA-silica particles (SP-uPA) as a new tool for assessing synthetic peptides to interfere with uPA/uPA-receptor interaction.

Document type:
Journal Article; Review
Author(s):
Guthaus, E; Schmiedeberg, N; Bürgle, M; Magdolen, V; Kessler, H; Schmitt, M
Abstract:
Many different processes in the physiology and pathophysiology of human beings are regulated protein/protein interactions such as receptor/ligand interactions. A more detailed knowledge of the nature of receptor/ligand binding sites and mechanisms of interaction is necessary as well in order to understand the process of cancer spread and metastasis. For instance, the cell surface receptor uPAR (CD87) and its ligand, the serine protease urokinase-type plasminogen activator (uPA), facilitate tumor...     »
Journal title abbreviation:
Recent Results Cancer Res
Year:
2003
Journal volume:
162
Pages contribution:
3-14
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12790317
Print-ISSN:
0080-0015
TUM Institution:
Frauenklinik und Poliklinik
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