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Titel:

Identification of 2,3-epoxymethacrylic acid as an intermediate in the metabolism of dental materials in human liver microsomes.

Dokumenttyp:
Journal Article; Article
Autor(en):
Seiss, M; Nitz, S; Kleinsasser, N; Buters, JT; Behrendt, H; Hickel, R; Reichl, FX
Abstract:
OBJECTIVES: In previous studies it could be demonstrated that methacrylic acid (MA) is an intermediate in the metabolism of unpolymerized dental comonomers, released from dental restorative materials. This study was performed to identify the possible dental material intermediate 2,3-epoxymethacrylic acid (2,3-EMA) from MA in human liver microsomes. Most epoxy compounds are regarded as highly toxic substances. METHODS: The formation and hydrolysis were studied in defined systems containing only M...     »
Zeitschriftentitel:
Dent Mater
Jahr:
2007
Band / Volume:
23
Heft / Issue:
1
Seitenangaben Beitrag:
9-16
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.dental.2005.11.038
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/16458349
Print-ISSN:
0109-5641
TUM Einrichtung:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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