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Title:

CYP1B1 determines susceptibility to low doses of 7,12-dimethylbenz[a]anthracene-induced ovarian cancers in mice: correlation of CYP1B1-mediated DNA adducts with carcinogenicity.

Document type:
Journal Article; Article
Author(s):
Buters, J; Quintanilla-Martinez, L; Schober, W; Soballa, VJ; Hintermair, J; Wolff, T; Gonzalez, FJ; Greim, H
Abstract:
We showed previously that CYP1B1-null mice developed 10 times less lymphomas than wild-type mice after receiving 7,12-dimethylbenz[a]anthracene (DMBA). In this study a 10-fold lower dose was applied to differentiate between toxicity induced lymphomas (200 micro g/mouse/day) and tumor initiation (20 micro g/day). DMBA adducts to DNA of organs of mice, or to DNA of V79 cells expressing single mice or human cytochrome P450 isoenzymes were also measured. Mice were dosed three cycles of 5 days/week w...     »
Journal title abbreviation:
Carcinogenesis
Year:
2003
Journal volume:
24
Journal issue:
2
Pages contribution:
327-34
Language:
eng
Fulltext / DOI:
doi:10.1093/carcin/24.2.327
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12584184
Print-ISSN:
0143-3334
TUM Institution:
Klinik und Poliklinik für Dermatologie und Allergologie; Molekulare Allergologie (Prof. Schmidt-Weber)
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