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Titel:

Epidermal growth factor activates nuclear factor-kappaB in human proximal tubule cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Häussler, U; von Wichert, G; Schmid, RM; Keller, F; Schneider, G
Abstract:
The promotion of cell survival and regeneration in acute renal failure (ARF) is important for the restitution of renal function. Epidermal growth factor (EGF) has been implicated in the regulation of cell proliferation. We provide evidence for a direct link between EGF, nuclear factor-kappaB (NF-kappaB), and cell cycle regulation (cyclin D1). EGF was found to stimulate NF-kappaB-dependent gene transcription and DNA binding. In addition, EGF stimulated cyclin D1 promoter activity as well as cycli...     »
Zeitschriftentitel:
Am J Physiol Renal Physiol
Jahr:
2005
Band / Volume:
289
Heft / Issue:
4
Seitenangaben Beitrag:
F808-15
Sprache:
eng
Volltext / DOI:
doi:10.1152/ajprenal.00434.2003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15798085
Print-ISSN:
1931-857X
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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