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Titel:

IKK-beta links inflammation to obesity-induced insulin resistance.

Dokumenttyp:
Journal Article; Article
Autor(en):
Arkan, MC; Hevener, AL; Greten, FR; Maeda, S; Li, ZW; Long, JM; Wynshaw-Boris, A; Poli, G; Olefsky, J; Karin, M
Abstract:
Inflammation may underlie the metabolic disorders of insulin resistance and type 2 diabetes. IkappaB kinase beta (IKK-beta, encoded by Ikbkb) is a central coordinator of inflammatory responses through activation of NF-kappaB. To understand the role of IKK-beta in insulin resistance, we used mice lacking this enzyme in hepatocytes (Ikbkb(Deltahep)) or myeloid cells (Ikbkb(Deltamye)). Ikbkb(Deltahep) mice retain liver insulin responsiveness, but develop insulin resistance in muscle and fat in resp...     »
Zeitschriftentitel:
Nat Med
Jahr:
2005
Band / Volume:
11
Heft / Issue:
2
Seitenangaben Beitrag:
191-8
Sprache:
eng
Volltext / DOI:
doi:10.1038/nm1185
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15685170
Print-ISSN:
1078-8956
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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