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Titel:

Regulation of cyclin D1 expression by autocrine IGF-I in human BON neuroendocrine tumour cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
von Wichert, G; Haeussler, U; Greten, FR; Kliche, S; Dralle, H; Böhm, BO; Adler, G; Seufferlein, T
Abstract:
Constitutive expression of cyclin D1 is a frequent abnormality in human cancer and sustains the transformed phenotype. We have previously demonstrated that cyclin D1 is constitutively expressed in human BON neuroendocrine tumour cells due to an autocrine insulin-like growth factor-I (IGF-I) loop. Here we examine the regulation of cyclin D1 expression by endogenously released IGF-I in BON cells. Cyclin D1 expression in these cells was found to be dependent on phosphatidylinositol 3-kinase (PI3-K)...     »
Zeitschriftentitel:
Oncogene
Jahr:
2005
Band / Volume:
24
Heft / Issue:
7
Seitenangaben Beitrag:
1284-9
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1208264
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/15580291
Print-ISSN:
0950-9232
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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