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Title:

Organometallic chemistry, biology and medicine: ruthenium arene anticancer complexes.

Document type:
Journal Article
Author(s):
Yan, YK; Melchart, M; Habtemariam, A; Sadler, PJ
Abstract:
Our work has shown that certain ruthenium(II) arene complexes exhibit promising anticancer activity in vitro and in vivo. The complexes are stable and water-soluble, and their frameworks provide considerable scope for optimising the design, both in terms of their biological activity and for minimising side-effects by variations in the arene and the other coordinated ligands. Initial studies on amino acids and nucleotides suggest that kinetic and thermodynamic control over a wide spectrum of reac...     »
Journal title abbreviation:
Chem Commun (Camb)
Year:
2005
Journal issue:
38
Pages contribution:
4764-76
Language:
eng
Fulltext / DOI:
doi:10.1039/b508531b
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16193110
Print-ISSN:
1359-7345
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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