User: Guest  Login
Title:

Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice.

Document type:
Journal Article; Article
Author(s):
Merl, S; Michaelis, C; Jaschke, B; Vorpahl, M; Seidl, S; Wessely, R
Abstract:
BACKGROUND: Enteroviridae such as coxsackievirus B3 (CVB3) are important infectious agents involved in viral heart disease, hepatitis, and pancreatitis, but no specific antiviral therapy is available. METHODS AND RESULTS: The aim of the present study was to evaluate the impact of RNA interference on viral replication, cytopathogenicity, and survival. Small interfering RNA (siRNA) molecules were designed against the viral 2A region (siRNA-2A), which is considered to be highly conserved and essent...     »
Journal title abbreviation:
Circulation
Year:
2005
Journal volume:
111
Journal issue:
13
Pages contribution:
1583-92
Language:
eng
Fulltext / DOI:
doi:10.1161/01.CIR.0000160360.02040.AB
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15795330
Print-ISSN:
0009-7322
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Allgemeine Pathologie und Pathologische Anatomie; Institut für Experimentelle Onkologie und Therapieforschung
 BibTeX