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Title:

Local statin therapy differentially interferes with smooth muscle and endothelial cell proliferation and reduces neointima on a drug-eluting stent platform.

Document type:
Journal Article; Article
Author(s):
Jaschke, B; Michaelis, C; Milz, S; Vogeser, M; Mund, T; Hengst, L; Kastrati, A; Schömig, A; Wessely, R
Abstract:
OBJECTIVE: Therapeutic strategies to provide local inhibition of mitogen mediated proliferation and migration of human coronary artery smooth muscle cells (CASMC) by means of drug-eluting stents have been shown to enable effective limitation of neointimal hyperplasia. However, currently available drug-eluting stents utilize compounds that may also adversely affect endothelial regrowth, thus possibly precipitating subsequent cardiac events. Accordingly, identification of compounds that differenti...     »
Journal title abbreviation:
Cardiovasc Res
Year:
2005
Journal volume:
68
Journal issue:
3
Pages contribution:
483-92
Language:
eng
Fulltext / DOI:
doi:10.1016/j.cardiores.2005.06.029
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/16111664
Print-ISSN:
0008-6363
TUM Institution:
I. Medizinische Klinik und Poliklinik (Kardiologie); Institut für Experimentelle Onkologie und Therapieforschung
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