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Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Liu, S; Li, Y; Lin, T; Fan, X; Liang, Y; Heemann, U
Titel:
High dose human insulin and insulin glargine promote T24 bladder cancer cell proliferation via PI3K-independent activation of Akt.
Abstract:
This study was to investigate the effects of human insulin and insulin glargine on proliferation of T24 human bladder cancer cells and the implication of the PI3K/Akt and MEK/ERK1/2 pathways.After exposure to insulin or glargine at the indicated concentrations for certain time courses, in the absence or presence of inhibitor for MEK (PD98059) or PI3K (LY294002), T24 cell proliferation was evaluated by CCK-8 assay. Phosphorylation of Akt and ERK1/2 was analyzed by Western blot.Insulin and glargin...     »
Zeitschriftentitel:
Diabetes Res Clin Pract
Jahr:
2011
Band / Volume:
91
Heft / Issue:
2
Seitenangaben Beitrag:
177-82
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.diabres.2010.11.009
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21129803
Print-ISSN:
0168-8227
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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