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Title:

Hypertension augments cardiac Toll-like receptor 4 expression and activity.

Document type:
Journal Article; Article
Author(s):
Eissler, R; Schmaderer, C; Rusai, K; Kühne, L; Sollinger, D; Lahmer, T; Witzke, O; Lutz, J; Heemann, U; Baumann, M
Abstract:
Hypertension causes cardiac hypertrophy characterized by low-grade inflammation. Toll-like receptors (TLRs), members of the innate immune system, contribute to cardiac failure. We hypothesized that hypertension is accompanied by enhanced TLR4 expression and activity. Cardiac TLR4 expression was determined in untreated spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats (WKY; 4, 8, 16 weeks). Besides, hearts of 8-week-old rats were stimulated with the endogenous TLR4 ligand...     »
Journal title abbreviation:
Hypertens Res
Year:
2011
Journal volume:
34
Journal issue:
5
Pages contribution:
551-8
Language:
eng
Fulltext / DOI:
doi:10.1038/hr.2010.270
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/21248757
Print-ISSN:
0916-9636
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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