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Titel:

Renin inhibition mitigates anti-angiogenesis in spontaneously hypertensive rats.

Dokumenttyp:
Journal Article; Article
Autor(en):
Rusai, K; Jianxing, C; Schneider, R; Struijker-Boudier, H; Lutz, J; Heemann, U; Baumann, M
Abstract:
Spontaneously hypertensive rats (SHRs) are characterized by capillary rarefaction, which may contribute to blood pressure elevation. We hypothesized that capillary rarefaction involves a suppressed angiogenesis; renin inhibition influences anti-angiogenesis homeostasis by acting on angiopoietins; transient renin blockade reduces anti-angiogenesis thereby ameliorating long-lasting blood pressure and cardiac hypertrophy in SHRs.First, serum angiopoietin-1 and angiopoietin-2 were measured in 2-mo...     »
Zeitschriftentitel:
J Hypertens
Jahr:
2011
Band / Volume:
29
Heft / Issue:
2
Seitenangaben Beitrag:
266-72
Sprache:
eng
Volltext / DOI:
doi:10.1097/HJH.0b013e328340aa72
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/21045736
Print-ISSN:
0263-6352
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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