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Titel:

Evidence for epidermal growth factor receptor as negative-feedback control in aldosterone-induced Na+ reabsorption.

Dokumenttyp:
Journal Article
Autor(en):
Grossmann, C; Freudinger, R; Mildenberger, S; Krug, AW; Gekle, M
Abstract:
Aldosterone enhances Na(+) reabsorption via epithelial Na(+) channels (ENaC). Aldosterone also stimulates the protein kinase ERK1/2- and the epidermal growth factor (EGF) receptor (EGFR)-signaling pathway. Yet EGF and ERK1/2 are known inhibitors of ENaC-mediated Na(+) reabsorption. In the present study, using the well-established Madin-Darby canine kidney C7 cell line, we tested the hypothesis that EGFR represents a negative-feedback control for chronic aldosterone-induced Na(+) reabsorption [am...     »
Zeitschriftentitel:
Am J Physiol Renal Physiol
Jahr:
2004
Band / Volume:
286
Heft / Issue:
6
Seitenangaben Beitrag:
F1226-31
Sprache:
eng
Volltext / DOI:
doi:10.1152/ajprenal.00378.2003
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14749256
Print-ISSN:
1931-857X
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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