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Title:

CpG-A and CpG-B oligonucleotides differentially enhance human peptide-specific primary and memory CD8+ T-cell responses in vitro.

Document type:
Journal Article
Author(s):
Rothenfusser, S; Hornung, V; Ayyoub, M; Britsch, S; Towarowski, A; Krug, A; Sarris, A; Lubenow, N; Speiser, D; Endres, S; Hartmann, G
Abstract:
Two distinct types of CpG oligodeoxynucleotide (ODN) have been identified that differ in their capacity to stimulate antigen-presenting cells: CpG-A induces high amounts of interferon-alpha (IFN-alpha) and IFN-beta in plasmacytoid dendritic cells (PDCs), whereas CpG-B induces PDC maturation and is a potent activator of B cells but stimulates only small amounts of IFN-alpha and IFN-beta. Here we examined the ability of these CpG ODNs to enhance peptide-specific CD8+ T-cell responses in human peri...     »
Journal title abbreviation:
Blood
Year:
2004
Journal volume:
103
Journal issue:
6
Pages contribution:
2162-9
Language:
eng
Fulltext / DOI:
doi:10.1182/blood-2003-04-1091
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/14630815
Print-ISSN:
0006-4971
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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