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Title:

Oligoclonal CD8+ T-cell expansion in patients with chronic hepatitis C is associated with liver pathology and poor response to interferon-alpha therapy.

Document type:
Clinical Trial; Controlled Clinical Trial; Journal Article
Author(s):
Manfras, BJ; Weidenbach, H; Beckh, KH; Kern, P; Möller, P; Adler, G; Mertens, T; Boehm, BO
Abstract:
The role of CD8(+) T lymphocytes in chronic hepatitis C virus (HCV) infection and in liver injury with subsequent development of fibrosis and cirrhosis is poorly understood. To address this question, we performed a follow-up study including 27 chronically HCV-infected individuals. We determined clonality and phenotypes of circulating CD8(+) T cells employing TCRBV spectratyping. Antigen specificity was tested by rMHC-peptide tetramer staining and stimulation with recombinant HCV antigens. In add...     »
Journal title abbreviation:
J Clin Immunol
Year:
2004
Journal volume:
24
Journal issue:
3
Pages contribution:
258-71
Language:
eng
Fulltext / DOI:
doi:10.1023/B:JOCI.0000025447.23473.ab
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15114056
Print-ISSN:
0271-9142
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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