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Title:

TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.

Document type:
Journal Article
Author(s):
Krug, A; French, AR; Barchet, W; Fischer, JA; Dzionek, A; Pingel, JT; Orihuela, MM; Akira, S; Yokoyama, WM; Colonna, M
Abstract:
Natural interferon-producing cells (IPC) respond to viruses by secreting type I interferon (IFN) and interleukin-12 (IL-12). Toll-like receptor (TLR) 9 mediates IPC recognition of some of these viruses in vitro. However, whether TLR9-induced activation of IPC is necessary for an effective antiviral response in vivo is not clear. Here, we demonstrate that IPC and dendritic cells (DC) recognize murine cytomegalovirus (MCMV) through TLR9. TLR9-mediated cytokine secretion promotes viral clearance by...     »
Journal title abbreviation:
Immunity
Year:
2004
Journal volume:
21
Journal issue:
1
Pages contribution:
107-19
Language:
eng
Fulltext / DOI:
doi:10.1016/j.immuni.2004.06.007
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/15345224
Print-ISSN:
1074-7613
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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