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Titel:

Herpes simplex virus type 1 activates murine natural interferon-producing cells through toll-like receptor 9.

Dokumenttyp:
Journal Article
Autor(en):
Krug, A; Luker, GD; Barchet, W; Leib, DA; Akira, S; Colonna, M
Abstract:
Natural interferon-producing cells (IPCs) specialize in the production of high levels of type 1 interferons (IFNs) in response to encapsulated DNA and RNA viruses. Here we demonstrate that the secretion of type 1 IFN in response to herpes simplex virus type 1 (HSV-1) in vitro is mediated by the toll-like receptor 9 (TLR9)/MyD88 pathway. Moreover, IPCs produce interleukin-12 (IL-12) in response to HSV-1 in vitro, which is also dependent on TLR9/ MyD88 signaling. Remarkably, though TLR9/MyD88-defi...     »
Zeitschriftentitel:
Blood
Jahr:
2004
Band / Volume:
103
Heft / Issue:
4
Seitenangaben Beitrag:
1433-7
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2003-08-2674
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14563635
Print-ISSN:
0006-4971
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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