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Titel:

A cell-surface molecule selectively expressed on murine natural interferon-producing cells that blocks secretion of interferon-alpha.

Dokumenttyp:
Journal Article
Autor(en):
Blasius, A; Vermi, W; Krug, A; Facchetti, F; Cella, M; Colonna, M
Abstract:
Natural interferon (IFN)-producing cells (IPCs) recognize certain viruses and DNA containing deoxycytidylate-phosphatedeoxyguanylate (CpG) motifs through the toll-like receptor (TLR) 9, resulting in secretion of IFN-alpha, interleukin 12 (IL-12), and proinflammatory chemokines. Human IPCs are found mainly in inflamed lymph nodes, where they are presumably recruited from the blood to activate both innate and adaptive responses to microbial infections. Demonstrating IPC recruitment and function in...     »
Zeitschriftentitel:
Blood
Jahr:
2004
Band / Volume:
103
Heft / Issue:
11
Seitenangaben Beitrag:
4201-6
Sprache:
eng
Volltext / DOI:
doi:10.1182/blood-2003-09-3108
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14695235
Print-ISSN:
0006-4971
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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