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Title:

Mechanisms of Bcr-Abl-mediated NF-kappaB/Rel activation.

Document type:
Journal Article; Article
Author(s):
Kirchner, D; Duyster, J; Ottmann, O; Schmid, RM; Bergmann, L; Munzert, G
Abstract:
Bcr-Abl constitutes a deregulated tyrosine kinase involved in the pathogenesis of chronic myeloid leukemia (CML) and a subset of acute lymphoblastic leukemia (ALL). Although activation of the transcription factor NF-kappaB/Rel has been demonstrated, mechanisms of NF-kappaB/Rel activation by Bcr-Abl remain obscure. In this paper we demonstrate activation of NF-kappaB/Rel by Bcr-Abl and for the first time by v-Abl. Furthermore, we investigated mechanisms of NF-kappaB/Rel induction by Bcr-Abl and v...     »
Journal title abbreviation:
Exp Hematol
Year:
2003
Journal volume:
31
Journal issue:
6
Pages contribution:
504-11
Language:
eng
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/12829026
Print-ISSN:
0301-472X
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie)
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