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Titel:

Evidence for radiosensitizing by gliotoxin in HL-60 cells: implications for a role of NF-kappaB independent mechanisms.

Dokumenttyp:
Journal Article
Autor(en):
Baust, H; Schoke, A; Brey, A; Gern, U; Los, M; Schmid, RM; Röttinger, EM; Seufferlein, T
Abstract:
Radioresistance markedly impairs the efficacy of tumor radiotherapy and may involve antiapoptotic signal transduction pathways that prevent radiation-induced cell death. A common cellular response to genotoxic stress induced by radiation is the activation of the nuclear factor kappa B (NF-kappaB). NF-kappaB activation in turn can lead to an inhibition of radiation-induced apoptotic cell death. Thus, inhibition of NF-kappaB activation is commonly regarded as an important strategy to abolish radio...     »
Zeitschriftentitel:
Oncogene
Jahr:
2003
Band / Volume:
22
Heft / Issue:
54
Seitenangaben Beitrag:
8786-96
Sprache:
eng
Volltext / DOI:
doi:10.1038/sj.onc.1206969
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/14647473
Print-ISSN:
0950-9232
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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