Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic, elderly men.

Ratkevicius A, Joyson A, Selmer I, Dhanani T, Grierson C, Tommasi AM, DeVries A, Rauchhaus P, Crowther D, Alesci S, Yaworsky P, Gilbert F, Redpath TW, Brady J, Fearon KCH, Reid DM, Greig CA, Wackerhage H

doi:10.1093/gerona/glr025

Publikationen 2011

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Title:: Serum concentrations of myostatin and myostatin-interacting proteins do not differ between young and sarcopenic, elderly men.
Document type:: Zeitschriftenaufsatz
Author(s):: Ratkevicius A, Joyson A, Selmer I, Dhanani T, Grierson C, Tommasi AM, DeVries A, Rauchhaus P, Crowther D, Alesci S, Yaworsky P, Gilbert F, Redpath TW, Brady J, Fearon KCH, Reid DM, Greig CA, Wackerhage H
Abstract:: Sarcopenia is the loss of muscle size and function during ageing. The aim of this study was to test whether serum concentrations of myostatin and interacting proteins (GASP-1, FLRG, and follistatin) differed between young and elderly sarcopenic men. Isometric knee extensor maximal voluntary contraction and quadriceps cross-sectional area (magnetic resonance imaging measurement) were significantly higher in young (22 ± 2 years; 266 ± 54 N/m; 8,686 ± 1,154 mm2) than in mildly sarcopenic (69 ± 3 years; 183 ± 17 N/m; 6,621±718 mm2) and severely sarcopenic men (76 ± 6 years; 127 ± 23 N/m; 5,846 ± 591 mm2), respectively (p ≤ .01 for all comparisons). There was a trend (p = .06) toward higher FLRG in young (20 ± 8 ng/mL) than in mildly (15 ± 6 ng/mL) and severely sarcopenic men (17 ± 8 ng/mL). Myostatin, follistatin, GASP-1, tumor necrosis factor α, and interleukin-6 did not differ significantly. Insulin-like growth factor-1 and free testosterone were both significantly lower in sarcopenic men (p < .001). This suggests that altered serum concentrations of myostatin and myostatin-interacting proteins are not contributing to sarcopenia with the possible exception of FLRG.
Keywords:: sarcopenia, myostatin
Dewey Decimal Classification:: 570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:: The Journals of Gerontology (J Gerontol) Series B
Year:: 2011
Journal volume:: 66
Pages contribution:: 620-626
Language:: en
Fulltext / DOI:: doi:10.1093/gerona/glr025
Pubmed ID:: http://view.ncbi.nlm.nih.gov/pubmed/21382886
Publisher:: Oxford Academic
Print-ISSN:: 1079-5014
E-ISSN:: 1758-5368
Impact Factor:: 2.615
TUM Institution:: Sportbiologie
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