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Title:

The Hippo Transducer YAP1 Transforms Activated Satellite Cells and Is a Potent Effector of Embryonal Rhabdomyosarcoma Formation

Document type:
Zeitschriftenaufsatz
Author(s):
Tremblay AM, Missiaglia E, Galli GG, Hettmer S, Urcia R, Carrara M, Judson RN, Thway K, Nadal G, Selfe JL, Murray G, Calogero RA, De Bari C, Zammit PS, Delorenzi M, Wagers AJ, Shipley J, Wackerhage H, Camargo FD
Abstract:
The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. Here we report that YAP1 activity is elevated in human embryonal rhabdomyosarcoma (ERMS). In mice, sustained YAP1 hyperactivity in activated, but not quiescent, satellite cells induces ERMS with high penetrance and short latency. Via its transcriptional program with TEAD1, YAP1 directly regulates several major hallmarks of ERMS. YAP1-TEAD1 upregulate pro-proliferative and oncogenic genes and maintain the ERMS...     »
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:
Cancer Cell
Year:
2014
Journal volume:
26
Pages contribution:
273-287
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.ccr.2014.05.029
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25087979
WWW:
http://www.cell.com/cancer-cell/fulltext/S1535-6108%252814%252900230-X
Print-ISSN:
1535-6108
Impact Factor:
27.41
TUM Institution:
Sportbiologie
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