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Titel:

Expression pattern in human macrophages dependent on 9p21.3 coronary artery disease risk locus.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't
Autor(en):
Zollbrecht, Christa; Grassl, Martina; Fenk, Sabine; Höcherl, Regina; Hubauer, Ute; Reinhard, Wibke; Esslinger, Ulrike B; Ebert, Stefanie; Langmann, Thomas; Stark, Klaus; Hengstenberg, Christian
Abstract:
Genome-wide association studies identified a risk haplotype on chromosome 9p21.3 to be associated with coronary artery disease (CAD) and myocardial infarction (MI). Since this region does not contain a clear candidate gene with known pathophysiology, we performed a haplotype-specific expression study in human macrophages during pro-inflammatory stimulation to investigate the locus-dependent expression patterns in a model of atherosclerosis, the underlying cause for CAD and MI.Blood samples were...     »
Zeitschriftentitel:
Atherosclerosis
Jahr:
2013
Band / Volume:
227
Heft / Issue:
2
Seitenangaben Beitrag:
244-9
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.atherosclerosis.2012.12.030
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/23375685
Print-ISSN:
0021-9150
TUM Einrichtung:
Klinik für Herz- und Kreislauferkrankungen im Erwachsenenalter (Prof. Schunkert)
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