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Title:

CX?CL1 (fractalkine) and its receptor CX?CR1 regulate atopic dermatitis by controlling effector T cell retention in inflamed skin.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Staumont-Sallé, Delphine; Fleury, Sébastien; Lazzari, Anne; Molendi-Coste, Olivier; Hornez, Nicolas; Lavogiez, Céline; Kanda, Akira; Wartelle, Julien; Fries, Anissa; Pennino, Davide; Mionnet, Cyrille; Prawitt, Janne; Bouchaert, Emmanuel; Delaporte, Emmanuel; Glaichenhaus, Nicolas; Staels, Bart; Julia, Valérie; Dombrowicz, David
Abstract:
Atopic dermatitis (AD) is a chronic allergic dermatosis characterized by epidermal thickening and dermal inflammatory infiltrates with a dominant Th2 profile during the acute phase, whereas a Th1 profile is characteristic of the chronic stage. Among chemokines and chemokine receptors associated with inflammation, increased levels of CX3CL1 (fractalkine) and its unique receptor, CX3CR1, have been observed in human AD. We have thus investigated their role and mechanism of action in experimental mo...     »
Journal title abbreviation:
J Exp Med
Year:
2014
Journal volume:
211
Journal issue:
6
Pages contribution:
1185-96
Language:
eng
Fulltext / DOI:
doi:10.1084/jem.20121350
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/24821910
Print-ISSN:
0022-1007
TUM Institution:
Molekulare Allergologie (Prof. Schmidt-Weber)
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