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Title:

Towards autotrophic tissue engineering: Photosynthetic gene therapy for regeneration.

Document type:
Journal Article; Article
Author(s):
Chávez, Myra Noemi; Schenck, Thilo Ludwig; Hopfner, Ursula; Centeno-Cerdas, Carolina; Somlai-Schweiger, Ian; Schwarz, Christian; Machens, Hans-Günther; Heikenwälder, Mathias; Bono, María Rosa; Allende, Miguel L; Nickelsen, Jörg; Egaña, José Tomás
Abstract:
The use of artificial tissues in regenerative medicine is limited due to hypoxia. As a strategy to overcome this drawback, we have shown that photosynthetic biomaterials can produce and provide oxygen independently of blood perfusion by generating chimeric animal-plant tissues during dermal regeneration. In this work, we demonstrate the safety and efficacy of photosynthetic biomaterials in vivo after engraftment in a fully immunocompetent mouse skin defect model. Further, we show that it is also...     »
Journal title abbreviation:
Biomaterials
Year:
2016
Journal volume:
75
Pages contribution:
25-36
Language:
eng
Fulltext / DOI:
doi:10.1016/j.biomaterials.2015.10.014
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26474040
Print-ISSN:
0142-9612
TUM Institution:
Institut für Virologie ; Lehrstuhl für Plastische Chirurgie und Handchirurgie (Prof. Machens)
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