High-risk plaque features can be detected in non-stenotic carotid plaques of patients with ischaemic stroke classified as cryptogenic using combined (18)F-FDG PET/MR imaging.

Hyafil, Fabien; Schindler, Andreas; Sepp, Dominik; Obenhuber, Tilman; Bayer-Karpinska, Anna; Boeckh-Behrens, Tobias; Höhn, Sabine; Hacker, Marcus; Nekolla, Stephan G; Rominger, Axel; Dichgans, Martin; Schwaiger, Markus; Saam, Tobias; Poppert, Holger

doi:10.1007/s00259-015-3201-8

journal article

Dokumenttyp:: Journal Article; Article
Autor(en):: Hyafil, Fabien; Schindler, Andreas; Sepp, Dominik; Obenhuber, Tilman; Bayer-Karpinska, Anna; Boeckh-Behrens, Tobias; Höhn, Sabine; Hacker, Marcus; Nekolla, Stephan G; Rominger, Axel; Dichgans, Martin; Schwaiger, Markus; Saam, Tobias; Poppert, Holger
Titel:: High-risk plaque features can be detected in non-stenotic carotid plaques of patients with ischaemic stroke classified as cryptogenic using combined (18)F-FDG PET/MR imaging.
Abstract:: The aim of this study was to investigate in 18 patients with ischaemic stroke classified as cryptogenic and presenting non-stenotic carotid atherosclerotic plaques the morphological and biological aspects of these plaques with magnetic resonance imaging (MRI) and (18)F-fluoro-deoxyglucose positron emission tomography ((18)F-FDG PET) imaging.Carotid arteries were imaged 150 min after injection of (18)F-FDG with a combined PET/MRI system. American Heart Association (AHA) lesion type and plaque composition were determined on consecutive MRI axial sections (n = 460) in both carotid arteries. (18)F-FDG uptake in carotid arteries was quantified using tissue to background ratio (TBR) on corresponding PET sections.The prevalence of complicated atherosclerotic plaques (AHA lesion type VI) detected with high-resolution MRI was significantly higher in the carotid artery ipsilateral to the ischaemic stroke as compared to the contralateral side (39 vs 0 %; p = 0.001). For all other AHA lesion types, no significant differences were found between ipsilateral and contralateral sides. In addition, atherosclerotic plaques classified as high-risk lesions with MRI (AHA lesion type VI) were associated with higher (18)F-FDG uptake in comparison with other AHA lesions (TBR = 3.43 ± 1.13 vs 2.41 ± 0.84, respectively; p < 0.001). Furthermore, patients presenting at least one complicated lesion (AHA lesion type VI) with MRI showed significantly higher (18)F-FDG uptake in both carotid arteries (ipsilateral and contralateral to the stroke) in comparison with carotid arteries of patients showing no complicated lesion with MRI (mean TBR = 3.18 ± 1.26 and 2.80 ± 0.94 vs 2.19 ± 0.57, respectively; p < 0.05) in favour of a diffuse inflammatory process along both carotid arteries associated with complicated plaques.Morphological and biological features of high-risk plaques can be detected with (18)F-FDG PET/MRI in non-stenotic atherosclerotic plaques ipsilateral to the stroke, suggesting a causal role for these plaques in stroke. Combined (18)F-FDG PET/MRI systems might help in the evaluation of patients with ischaemic stroke classified as cryptogenic.
Zeitschriftentitel:: Eur J Nucl Med Mol Imaging
Jahr:: 2016
Band / Volume:: 43
Heft / Issue:: 2
Seitenangaben Beitrag:: 270-9
Sprache:: eng
Volltext / DOI:: doi:10.1007/s00259-015-3201-8
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/26433367
Print-ISSN:: 1619-7070
TUM Einrichtung:: Fachgebiet Neuroradiologie (Prof. Zimmer); Klinik und Poliklinik für Nuklearmedizin; Neurologische Klinik und Poliklinik
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